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Abstract #10374 Published in IGR 6-1
Gonioscopic findings in patients with type 1 neurofibromatosis (Von Recklinghausen disease)
Quaranta L; Semeraro F; Turano R; Gandolfo EJournal of Glaucoma 2004; 13: 90-95
PURPOSE: Based on the known neurocristopathic etiology of type 1 neurofibromatosis (NF1) and the neuroectodermal embryologic derivation of the iridocorneal angle, the authors examined a sample of young patients affected with NF1 to see if they had evidence of underdevelopment of the angular region. PATIENTS AND METHODS: The authors designed a case-controlled clinical study. Forty-two consecutive patients (42 eyes), 24 male and 18 female, affected with NF1 were recruited for the study. Forty-two eyes of 42 consecutive young patients (19 male and 23 female) served as a control group for the iridocorneal angle features studied. Indirect gonioscopy was performed by the means of a Goldmann lens. Intraocular pressure was measured with a Goldmann applanation tonometer. Photographs were taken of the anterior segment and of all the four quadrants of the iridocorneal angle to record the presence of abnormalities. The iridocorneal angle was graded according to the classification proposed by Spaeth. Evaluation of the angle also included the gonioscopic width of ciliary body band (CBB). RESULTS: In this study the authors found that 29 of 42 eyes (69%) of the NF1 group had mild anteriorization, even if within normal limits, of the iris insertion and abundant basal iris processes. The CBB was either invisible (54.84%) or very narrow (21.4%). Three NF1 patients had bilateral juvenile congenital glaucoma. CONCLUSIONS: It seems that patients affected with NF1 often have characteristic gonioscopic findings consistent with underdevelopment of the iridocorneal angle.
Dr. L. Quaranta, Centro Glaucoma, Clinica Oculistica dell'Universita di Brescia, Brescia, Italy. quaranta@med.unibas.it
Classification:
6.4 Gonioscopy (Part of: 6 Clinical examination methods)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
