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Abstract #109961 Published in IGR 24-1/2
Exploring the Relationship between Anti-VEGF Therapy and Glaucoma: Implications for Management Strategies
Daka Q; Špegel N; Atanasovska Velkovska M; Steblovnik T; Kolko M; Neziri B; Cvenkel BJournal of clinical medicine 2023; 12:
A short-term increase in intraocular pressure (IOP) is a common side effect after intravitreal anti-VEGF therapy, but a sustained increase in IOP with the development of secondary glaucoma has also been reported in some studies after repeated intravitreal anti-VEGF injections. The aim of this review is to present and discuss the possible pathophysiological mechanisms and factors contributing to a sustained rise in IOP, as well as treatment strategies for patients at risk. Close monitoring and adjustable IOP-lowering treatment are recommended for high-risk patients, including those with glaucoma, angle-closure anomalies, ocular hypertension or family history of glaucoma; patients receiving a high number of injections or at shorter intervals; and patients with capsulotomy. Strategies are needed to identify patients at risk in a timely manner and to prevent sustained elevation of IOP.
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