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Abstract #11460 Published in IGR 6-3
Effect of different dose schedules of 0.15% unoprostone isopropyl on intraocular pressure and pupil size in the glaucomatous beagle
Gelatt KN; MacKay EO; Dashiell T; Biken-AJournal of Ocular Pharmacology and Therapeutics 2004; 20: 411-420
The changes in intraocular pressure (IOP) and pupil size (PS) after instillations of 0.15% unoprostone isopropyl (Rescula, Novartis Ophthalmics, Duluth, GA) were investigated in the spontaneous glaucoma Beagle model. From the first-day baseline IOP of 27.3 ± 3.2 mmHg placebo eye and 32.8 ± 5.1 mmHg control eye, the mean ± standard error of the mean (SEM) diurnal changes after 0.15% unoprostone, at 8 AM once-daily for the next 4 days, were 15.5 ± 1.3 mmHg, 14.7 ± 1.9 mmHg, 16.1 ± 1.1 mmHg, and 17.0 ± 1.5 mmHg, respectively, and were significantly different from the control eye. After 0.15% unoprostone was instilled at 8 PM, the mean ± SEM baseline changes from the baseline IOP (insert drug eye 9 AM) in the drug eyes were 5.9 ± 2.5 mmHg, 5.2 ± 4.1 mmHg, 9.7 ± 2.5 mmHg, and 3.6 ± 3.6 mmHg, respectively. When 0.15% unoprostone was instilled twice-daily, the mean ± SEM baseline IOP (insert drug eye 9 AM) changes were 13.6 ± 0.7 mmHg, 13.9 ± 1.4 mmHg, 11.3 ± 1.0 mmHg, and 9.3 ± 1.4 mmHg, respectively, and were significantly different from the control eyes. Miosis occurred within 2 hours and lasted several hours. Unoprostone isopropyl instilled once-daily (AM or PM), as well as twice-daily, produces significant decreases in IOP and PS in the glaucomatous Beagle.
Dr. K.N. Gelatt, University of Florida, P.O. Box 100126, Gainesville, FL 32610-0126, USA
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
