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Abstract #119379 Published in IGR 25-1
α-1 antitrypsin is promising for the identification of glaucoma severity and is associated with glaucomatous neural damage
Yuan H; Li A; Chen L; Wang Z; Zhu X; Wang J; Xiu W; Chen Y; Zhang G; Liu D; Xiao X; Sun C; Lu F; Hu L; He CBiomarkers in medicine 2024; 18: 545-553
To investigate the association between plasma AAT level and glaucoma. 163 glaucoma patients and 111 healthy controls were recruited. The plasma AAT levels were measured by ELISA. Plasma AAT level was significantly higher in glaucoma patients than those in healthy controls ( < 0.001). Patients with higher plasma AAT level exhibited severer disease stage (early vs. severe: < 0.05; H-P-A; early vs. severe: < 0.05; early vs. end-stage: < 0.01; AGIS). ROC curves yielded that AAT can distinguish patients with early glaucoma from those with advanced glaucoma (early vs. severe: AUC: 0.616; H-P-A; early vs. severe: AUC: 0.763; early vs. end-stage: AUC: 0.660; AGIS). Plasma AAT is a useful biomarker for the identification of glaucoma severity.
Department of Immunology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, China.
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