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Abstract #120561 Published in IGR 25-1
Causal associations between mobile phone usage and glaucoma risk: A Mendelian randomization study
Song R; Wang Y; Kong Y; Fan X; Yuan C; Zha XMedicine 2024; 103: e40666
Previous research has indicated a possible link between mobile phone usage and the incidence of glaucoma. This study employs a 2-sample Mendelian randomization (MR) analysis to examine the causal relationship between mobile phone use and glaucoma risk. We used single nucleotide polymorphisms (SNPs) from publicly accessible genome-wide association study (GWAS) datasets as instrumental variables (IVs). The primary analytical method was the inverse variance weighted (IVW) approach, with MR-Egger and weighted median analyses serving as complementary methods. Sensitivity was evaluated using Cochran's Q test and MR-Egger regression. The results demonstrate a causal effect of mobile phone usage on an increased risk of glaucoma (ORIVW = 1.358, 95% CI: 1.052-1.752, P = .019; ORMR-Egger = 1.882, 95% CI: 0.53-6.682, P = .337; ORWeighted median = 1.387, 95% CI: 1.012-1.900, P = .042; ORMR-PRESSO = 1.358, 95% CI: 1.052-1.752, P = .026). Sensitivity analyses confirmed the robustness and reliability of these findings. The study identifies mobile phone usage as a potentially modifiable risk factor for glaucoma, providing new avenues for exploring the specific mechanisms underlying these ocular disorders.
Department of Ophthalmology Department, The Second Affiliated Hospital of Kunming Medical University, Kunming, China.
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