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Abstract #120825 Published in IGR 25-1
Can Baseline Parapapillary Atrophy Morphology Predict Future Glaucoma Progression?-An OCT Glaucoma Imaging Study
Huh MG; Huh MG; Jeong Y; Shin YI; Shin YI; Park KH; Jeoung JWAmerican Journal of Ophthalmology 2024; 267: 19-29
PURPOSE: To investigate glaucoma progression based on Optical Coherence Tomography (OCT) Guided Progression Analysis (GPA) according to baseline β-zone parapapillary atrophy (PPA) morphology in glaucoma patients. DESIGN: Retrospective cohort study. METHODS: Patients over 20 years of age who had been diagnosed with primary open-angle glaucoma (POAG) at Seoul National University Hospital, Seoul, Korea between 2010 and 2020. This study included POAG patients with a minimum of 5 years of follow-up. We quantitatively measured the baseline β-zone PPA parameters, classified β-zone PPA morphology according to new classification standard we created and analyzed the corresponding GPA progression of the retinal nerve fiber layer (RNFL). RESULTS: A total of 210 patients with POAG (mean age: 53.8 years) were enrolled in the study. The mean follow-up period was 9.8 years. The average value of the baseline mean deviation in visual field perimetry was -2.48 dB. Longer radial extent and larger angular extent of β-zone PPA were significantly associated with progression on GPA, as was the presence of disk hemorrhage. Among the 4 classified β-zone PPA morphologies (Crescent type 1 & 2, Solar-eclipse type 1 & 2), the Solar-eclipse type 2 group showed the highest progression. A Kaplan-Meier survival analysis demonstrated significant differences among the 4 types. CONCLUSIONS: The larger the radial and angular extents of β-zone PPA, the more progression that was shown on OCT GPA. Furthermore, significant differences in progression were noted based on the morphological type of β-zone PPA. Our findings indicate that baseline β-zone PPA parameters and morphology are valuable predictors of future glaucoma progression.
From the Department of Ophthalmology, Seoul National University Hospital (M.G.H., Y.J., Y.I.S., K.H.P., J.W.J.), Seoul, South Korea; Department of Ophthalmology, Seoul National University College of Medicine (M.G.H., Y.J., Y.I.S., K.H.P., J.W.J.), Seoul, South Korea; Department of Ophthalmology, Yeungnam University Hospital (M.G.H.), Daegu, South Korea.
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