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Abstract #121769 Published in IGR 25-1
Lack of genetic association of non-melanoma skin cancer and pseudoexfoliative glaucoma
Beneke AA; Wiese JD; Root KT; Taneja K; Beal CJOphthalmic Genetics 2024; 45: 623-625
BACKGROUND: Prior research has shown a positive association of pseudoexfoliative glaucoma (PXG) in patients with non-melanoma skin cancer (NMSC), likely due to an increase in ultraviolet exposure associated with both. However, the role of NMSC as a genetic risk factor for PXG has not been examined. Thus, the goal of this study is to utilize Mendelian randomization with genome-wide association studies to evaluate for genetic causality while controlling for environmental confounders. METHODS: We conducted a MR using the inverse variance weighted method (MR-IVW) as our primary analysis. Genomic data was sourced from GWASs for patients with NMSC (10,382 cases, 208,410 controls) and PXG (1,515 cases and 210,201 controls), originating from the FinnGen Biobank. RESULTS: Despite previous association of history of NMSC with occurrence of PXG, we found no evidence for a causal association between SNPs associated with NMSC and risk of PXG following MR analysis (MR-IVW, odds ratio (OR): 0.98, 95% CI: 0.85-1.14, P = 0.87). CONCLUSION: Here, we found no evidence for a causal association between SNPs associated with NMSC and the risk of PXG following a MR analysis.
College of Medicine, University of Florida, Gainesville, Florida, USA.
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