advertisement
Abstract #122001 Published in IGR 25-1
Low Body Mass Index Poses Greater Risk of Primary Open-Angle Glaucoma in African Ancestry Individuals
Di Rosa I; Halimitabrizi M; Salowe R; Augello P; Augello P; Zhu D; Chen Y; Sankar P; Addis V; Ying GS; O'Brien JAmerican Journal of Ophthalmology 2024; 271: 119-126
PURPOSE: Investigate the relationship between body mass index (BMI) and primary open-angle glaucoma (POAG) in an African ancestry cohort from the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study. DESIGN: Retrospective, cross-sectional "case-control" comparison study. METHODS: A total of 6,634 POAAGG study subjects were eligible: 2,977 cases and 3,657 controls. Ocular and demographic data were collected from on-site exams, standardized interviews, and electronic medical records. BMI was calculated: weight(kg)/height(m), and categorized as low (<18.5), moderate (18.5-24.9), high (25.0-29.9), or very high (≥30). Structural and functional POAG progression were assessed by annual rate of change in retinal nerve fiber layer thickness and visual field mean deviation, respectively, using a linear mixed-effects model. Regression analyses evaluated associations of BMI with POAG status, phenotype, and progression. RESULTS: Lower BMI was associated with increased POAG risk (aOR[95% confidence interval], 1.02 [1.007,1.023] per kg/m decrease in BMI, p = .0003). In cases, low BMI was associated with larger cup-to-disc ratio (p = .007) and worse visual acuity (p = .04). Fast functional POAG progressors had a significantly lower mean BMI than slow progressors (25.7 vs. 30.0 kg/m, p = .04). CONCLUSIONS: In this African ancestry cohort, low BMI was associated with increased POAG risk. POAG cases with low BMI were more likely to have larger cup-to-disc ratios, worse visual acuity, and faster functional progression, indicating more severe glaucoma.
From the Center for Genetics of Complex Disease, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Full article