advertisement
Abstract #122600 Published in IGR 25-1
Contrast Sensitivity Is Impaired in Suspected Primary Open-Angle Glaucoma Patients
Tripolone MC; Issolio LA; Perez DO; Barrionuevo PABrain sciences 2024; 14:
PURPOSE: To assess spatial contrast sensitivity (CS) in suspected primary open-angle glaucoma (POAG) patients. METHODS: CS was measured using sinusoidal gratings of 4 cycles/degree. First, foveal and peripheral CS were assessed in 34 suspected POAG patients and compared with 71 and 28 age-matched healthy individuals for foveal and peripheral conditions, respectively. Second, foveal CS was assessed in 34 early POAG patients age-matched with suspected POAG patients. Analyses were performed considering two age ranges: Under and Over 50 y.o. Correlations were evaluated between CS and clinical parameters. Diagnostic accuracy was also analyzed. RESULTS: Peripheral CS was lower in older suspected POAG patients (23.4 ± 16.1) than the control group (39.1 ± 28.2) ( = 0.040). Foveal CS was reduced in suspected POAG participants (Under 50: 146.8 ± 63.3; = 0.004. Over 50: 110.5 ± 65.0; = 0.044) and in early POAG patients (Under 50: 141.2 ± 72.6; = 0.002. Over 50: 80.2 ± 54.5 < 0.001), both compared to the control group (Under 50: 213.5 ± 66.2. Over 50: 138.6 ± 71.7). CS was lower in early POAG than in POAG suspected in older patients ( = 0.042). Foveal CS was correlated with age (Early: = 0.001. Suspect: = 0.002) and with the cup-disc ratio only in early POAG patients ( < 0.001). Foveal CS had fair (AUC = 0.74) diagnostic accuracy for early POAG patients. CONCLUSIONS: CS in suspected POAG patients is lower than in healthy individuals. Our findings evidence the spatial vision loss before the onset of POAG.
Instituto de Investigación en Luz, Ambiente y Visión, Universidad Nacional de Tucumán-Consejo Nacional de Investigaciones Científicas y Técnicas, San Miguel de Tucumán T4000BLR, Argentina.
Full article