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Abstract #14295 Published in IGR 8-3
Correlating structure with function in end-stage glaucoma
Blumenthal EZ; Horani A; Sasikumar R; Garudadri C; Udaykumar A; Thomas ROphthalmic Surgery Lasers and Imaging 2006; 37: 218-223
BACKGROUND AND OBJECTIVE: To correlate structure and function in eyes with end-stage glaucoma. PATIENTS AND METHODS: Fifty six eyes of 48 patients with glaucoma presenting with end-stage glaucoma underwent scanning laser polarimetry (SLP) imaging using a commercially available GDx-variable corneal compensator unit (GDx-VCC; Laser Diagnostics Technologies, Inc., San Diego, CA). End-stage glaucoma was defined by both disc appearance and standard automated perimetry visual field criteria. Standard automated perimetry parameters included: mean deviation, pattern standard deviation, and total deviation plot. GDx parameters included: TSNIT average, superior average, inferior average, TSNIT standard deviation, and nerve fiber indicator. RESULTS: The visual field mean deviation was 26.75 ± 3.50 dB. The remaining retinal nerve fiber layer measured in this group of eyes was: TSNIT average, 29.76 ± 5.81 μm; superior average, 30.76 ± 6.25 μm; and inferior average, 31.14 ± 7.20 μm. A low structure-function correlation was found when analyzing separately the superior and inferior hemifields (R2 = 0.00001, R2 = 0.0016, respectively). CONCLUSIONS: In eyes with end-stage glaucoma, very thin but existing retinal nerve fiber layer is found on SLP. Such values rarely dropped below 10 to 20 μm. A flattening of the GDx TSNIT pattern was seen, and the correlation between structure and function was not evident.
Dr. E.Z. Blumenthal, Department of Ophthalmology, Hadassah University Hospital, P.O. Box 12000, Jerusalem 91120, Israel
Classification:
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
6.9.1 Laser scanning (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)