advertisement
Abstract #15420 Published in IGR 1-3
Color Doppler imaging of ocular blood flow after topical ketanserin
Cellini M; Caramazza ROphthalmologica 1999; 213: 286-289
The authors investigated the effect of ketanserin 0.5% eye drops on intraocular pressure and orbital blood flow in some healthy volunteers. Ketanserin is a selective antagonist of serotonin S2 receptors; moreover, it produces an 1-blocking effect. It causes a systemic reduction of blood pressure and capillary vasodilatation. Three hours after topical administration of ketanserin 0.5%, the intraocular pressure was decreased by about 14% from the baseline. At the same time, the authors observed by color Doppler imaging that the mean percent increase in the peak systolic velocity in the ophthalmic artery (OA) was 5.18% (p < 0.161) and 23.18% (p < 0.001) in the posterior ciliary arteries (PCAs). The mean resistance index of the OA was in contrast reduced by 1.16% (p < 0.669) and by 32.14% (p < 0.003) in the PCAs. These data show that ketanserin 0.5% eye drops may be useful not only in decreasing intraocular pressure, but also in improving blood flow in the PCAs that supply the optic nerve head.
Dr. M. Cellini, Institute of Ophthalmology, University of Bologna, Bologna; Italy
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
