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Abstract #15422 Published in IGR 1-3
Effects of 0.005% latanoprost on optic nerve head and peripapillary retinal blood flow
Gong Je Seong; Hyung Keun Lee; Young Jae HongOphthalmologica 1999; 213: 355-359
Fifty-two eyes of 26 healthy volunteers were recruited for evaluating the effects of 0.005% latanoprost on optic nerve head (ONH) and peripapillary retinal blood flow. In a randomized double-blind design, one eye received one drop of 0.005% latanoprost, and its fellow eye received one drop of a placebo eyedrop. Intraocular pressure (IOP), ONH and peripapillary retinal blood flow were measured with Heidelberg retinal flowmetry (HRF) before, and two and 24 hours after administration of eyedrops. IOP was decreased significantly in latanoprost-treated eyes at two and 24 hours after administration (p < 0.05). In the volume, flow or velocity of ONH and peripapillary retina, there were no significant changes from the baseline values at two and 24 hours after latanoprost administration in either latanoprost-treated or fellow eyes (p>0.05). No significant differences were found in the measured quantities between latanoprost-treated and fellow eyes at each time point (p>0.05). This result could suggest that 0.005% latanoprost in healthy subjects does not have any adverse effect on ONH and peripapillary retinal blood flow.
Dr. Gong Je Seong, Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul; Korea
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
11.4 Prostaglandins (Part of: 11 Medical treatment)
