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Abstract #15540 Published in IGR 1-3
Saving the nerve from glaucoma: memantine to caspaces
Naskar R; Vorwerkd CK; Dreyer EBSeminars in Ophthalmology 1999; 14: 152-158
Three recent discoveries regarding the pathophysiology of human glaucoma are that retinal ganglion cells die by apoptosis, that nitric oxide synthase levels are altered, and that glutamate is elevated in the vitreous. These findings provide encouraging new avenues for the development of neuroprotective strategies to alleviate ganglion cell loss and blindness that accompanies this disease. In this article, the authors discuss some of these data, as well as potential therapies that may arise from these findings.
Dr. E.B. Dreyer, Scheie Eye Institute, 51 North 39th Street, Philadelphia, PA 19104; USA
Classification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
