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Abstract #15737 Published in IGR 2-3
Aqueous humor nitric oxide levels differ in patients with different types of glaucoma
Chang CJ; Chiang CH; Chow JC; Lu D-WJournal of Ocular Pharmacology and Therapeutics 2000; 16: 399-406
Nitric oxide (NO) has effects on the regulation of aqueous humor dynamics, but the exact mechanism is not yet established. To investigate the possible roles of NO in glaucoma, the authors determined NO levels in aqueous humor and plasma in glaucoma patients and a control group, cataract patients. The study is an open trial with purposed sampling. One hundred and fifty-two patients, including 87 glaucoma patients and 65 cataract patients from two medical centers, were recruited. NO levels in the samples were measured by a chemiluminescence assay. The authors found that, although the mean aqueous humor NO level (mean ± SEM) was higher in the glaucoma patients than in the cataract patients (39.7 ± 1.5 μm versus 35.5 ± 1.3 μm, p < 0.05), NO levels varied significantly in different types of glaucoma. The juvenile glaucoma patients had the lowest mean NO level (8.4 ± 0.9 μm), while the acute angle-closure glaucoma and neovascular glaucoma patients had the highest mean NO levels (64.8 ± 7.6 μm, 67.3 ± 8.2 μm). In comparison, the mean plasma NO level in the glaucoma patients was not statistically different from that in the cataract patients (14.1 ± 1.2 μm versus 13.9 ± 1.1 μm. p = 0.91). These data may provide information for applying NO-mimicking nitrovasodilators in the treatment of glaucoma.
Dr. C.J. Chang, Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
Classification:
1.3 Pathogenesis (Part of: 1 General aspects)
2.6 Aqueous humor dynamics (Part of: 2 Anatomical structures in glaucoma)
