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AIM: To evaluate if the cannabinoid (WIN55, 212-2) could lower the glutamic acid concentration in vitreous body by topical application (eyedrop) to chronic glaucoma rabbit model. METHODS: Fifteen rabbits were randomly divided into three groups with five rabbits (10 eyes) in each group. All the rabbits were made into chronic glaucoma model except the normal control group. After 7 days, the high intraocular pressure (IOP) group and the cannabinoid group were administered with normal saline and 1.25 g/L WIN55-212-2 eyedrops repectively. The changes in the glutamic acid concentration in vitreous body were observed and quantified. RESULTS: There was significant difference in the glutamic acid concentration in vitreous body between high IOP group and normal control group (P < 0.05), but no significant difference between cannabinoid group and normal control group (P > 0.05). CONCLUSION: Cannabinoid topical application can lower the glutamic acid concentration in vitreous body that was increased by high IOP in chronic glaucoma rabbit model. LA: Chinese
Dr. J.-H. Zhao, Department of Ophthalmology, Shanxi Medical University, Taiyuan, 030001 Shanxi Province, China. ciwei0516@hotmail.com
3.7 Biochemistry (Part of: 3 Laboratory methods)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
11.8 Neuroprotection (Part of: 11 Medical treatment)