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WGA Rescources

Abstract #23044 Published in IGR 11-1

Endogenous bioactive lipids and the regulation of conventional outflow facility

Wan Z; Woodward DF; Stamer WD
Expert Review of Ophthalmology 2008; 3: 457-470


Perturbation of paracrine signaling within the human conventional outflow pathway influences tissue homeostasis and outflow function. For example, exogenous introduction of the bioactive lipids, sphingosine-1-phosphate, anandamide or prostaglandin F(2α), to conventional outflow tissues alters the rate of drainage of aqueous humor through the trabecular meshwork and into Schlemm's canal. This review summarizes recent data that characterize endogenous bioactive lipids, their receptors and associated signaling partners in the conventional outflow tract. We also discuss the potential of targeting such signaling pathways as a strategy for the development of therapeutics to treat ocular hypertension and glaucoma.

Dr. W.D. Stamer, Department of Ophthalmology and Vision Science, Department of Pharmacology, The University of Arizona, 655 North Alvernon Way, Tucson, AZ 85711, USA. dstamer@eyes.arizona.edu


Classification:

2.6.2.1 Trabecular meshwork (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics > 2.6.2 Outflow)
11.4 Prostaglandins (Part of: 11 Medical treatment)
3.8 Pharmacology (Part of: 3 Laboratory methods)



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