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Abstract #23995 Published in IGR 11-2
Imaging of optic nerve head drusen: improvements with spectral domain optical coherence tomography
Yi K; Mujat M; Sun W; Burnes D; Latina MA; Lin DT; Deschler DG; Rubin PA; Park BH; de Boer JFJournal of Glaucoma 2009; 18: 373-378
OBJECTIVE: To demonstrate a new algorithm that can determine the shape, location, and volume of optic nerve head drusen (ONHD), which were imaged with spectral domain optical coherence tomography (SDOCT). METHODS: One exenteration patient and 4 glaucoma patients with bilateral ONHD were recruited from the Massachusetts Eye and Ear Infirmary and from a private practice office. Images were obtained using an experimental SDOCT system developed at the Wellman Center for Photomedicine, Massachusetts General Hospital. With axial resolutions of about 6 mum, SDOCT can obtain 2-dimensional images in 1/29 of a second, compared with commercially available time domain OCT instruments with 10 mum resolution images in 1.28 seconds. The volumes of ONHD were calculated with a new algorithm and were then correlated with visual field mean deviation. RESULTS: SDOCT can display 2-dimensional images comparable with histology and 3-dimensional videos of ONHD. ONHD are signal-poor regions with high-signaled borders. Larger ONHD volumes are directly correlated with larger mean deviation absolute values on Humphrey visual field testing. CONCLUSIONS: SDOCT is a potentially better technique for ONHD imaging and may improve the diagnosis and management of patients with both OHND and glaucoma.
Harvard Medical School, Department of Ophthalmology, Glaucoma Service, Massachusetts General Hospital, Boston, MA, USA.
Classification:
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)