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Abstract #26030 Published in IGR 12-2
Effects of bushenhuoxue on protecting the visual function of rat with chronic intraocular hypertension
Mao X; Li XInternational Journal of Ophthalmology 2010; 10: 238-240
AIM: To observe the effect of traditional Chinese medicine (TCM) of bushenhuoxue on the rat model of chronic, moderately elevated intraocular pressure( EIOP). METHODS: By unilaterally cauterizing episcleral vessels, the rat model of chronic, moderately EIOP was gotten. 52 rats were divided into 5 groups randomly: model control group, treatment groups with high, middle, low dosage of bushenhuoxue of TCM, and normal control group. After given drugs or normal saline for 8 weeks, the rats were put to death and eyeballs were taken out. The effects were observed by intraocular pressure ( IOP ), multifocal electroretinogram(mfERG), and retinal ganglion cells( RGCs). RESULTS: Elevated IOP was gotten and there was an approximately 3-fold increase in IOP for 8 weeks later comparing to pre-models building. Bushenhuoxue of TCM can lower IOP slightly; To observe the mfERG first order kernel (FOK), bushenhuoxue of TCM can improve P1 wave's 1, 2 ,3, 4 ring's amplitude density , P1 wave' s peak time, N1 wave's 2, 3 ring's amplitude density and N1 wave's 2, 3 ring ' s peak time. CONCLUSION: Bushenhuoxue of TCM can protect the visual function from elevating IOP by improving mfERG's amplitude density and peak time. So the mfERG can be a sensitivity method to evaluate its efficacy. LA: Chinese
X. Mao. Department of Ophthalmology, Traditional Chinese Medicine Hospital of Mentougou District, Beijing 102300, China. maoxin_2008@hotmail.com
Classification:
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
11.8 Neuroprotection (Part of: 11 Medical treatment)
5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)
