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Abstract #27326 Published in IGR 12-4

Erythropoietin protects retinal ganglion cells and visual function after ocular ischemia and optic nerve compression

Jehle T; Meschede W; Dersch R; Feltgen N; Bach M; Lagreze WA
Ophthalmologe 2010; 107: 347-353

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Background: The glycoprotein erythropoietin (EPO) has been shown to be protective in models of neuronal disease and reduced apoptosis of retinal ganglion cells (RGC) after transection of the optic nerve and in glaucoma. In this study we assessed in vivo the properties of EPO on survival of RGC after ischemia and optic nerve compression, as well as on postischemic visual function. Furthermore, the safety of intravitreal injection was assessed. Methods: In all experiments, EPO was administered intravitreally in male Brown Norway rats. Ocular ischemia was induced by elevating the intraocular pressure for 55 min. The calibrated optic nerve compression was performed for 10 s. RGC were marked stereotactically and quantified by fluorescence microscopy. The retinal function was quantified by electroretinography (ERG) and the whole visual pathway by visual evoked potential (VEP). Results: EPO (2 and 20 units per eye, n=9-21) increased the survival of RGC after ischemia by 21(plus or minus)21% and 127(plus or minus)31% (mean (plus or minus) SEM) and after optic nerve compression by 28(plus or minus)12% and 58(plus or minus)13%. With EPO (20 units), postischemic function was increased, in ERG by 71(plus or minus)13% (a-wave) and 75(plus or minus)19% (b-wave) and in VEP by 264(plus or minus)65% (p=0.053). Neither the ERG parameters, nor the VEP, nor the number of RGC differed significantly after intravitreal injection of EPO (5, 50, and 200 units, n=6-7) in healthy eyes. Conclusion: The combination of toxicological safety and protection of retinal neurons makes EPO a promising drug for ischemic retinal diseases and traumatic optic neuropathy. (copyright) 2009 Springer-Verlag. LA: German, English

T. Jehle. Augenklinik des Klinikums der Albert-Ludwigs-Universitat Freiburg i.Br., Killianstrasse 5, 79106 Freiburg i.Br., Germany. tomjeh@googlemail.com

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Classification:

11.8 Neuroprotection (Part of: 11 Medical treatment)
5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)

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