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Abstract #27365 Published in IGR 12-4
Effect of topically applied moxonidine on intraocular pressure and blood pressure
Zhang Q; Sun N-X; Liu JChinese Ophthalmic Research 2010; 28: 611-615
Background: Moxonidine is an agonist of (alpha)(2) receptor. It has been used to the clinical treatment of glaucoma. Therefore, the effects of moxonidine on ocular tissue and blood pressure and heart rate is also interested research topic. Objective: This study was to evaluate the effects of different concentrations of moxonidine on intraocular pressure (IOP), pupil diameter (PD), heart rate (HR) and blood pressure (BP) simultaneously after topical administration. Methods: 0.05%, 0.1%, 0.2% moxonidine were topically used in the lateral eyes of healthy white rabbits in 0.05% moxonidine group (8 rabbits), 0.1% moxonidine group (8 rabbits), 0.2% moxonidine group (8 rabbits) respectively and sterilized distilled water was topically used in the control group (8 rabbits). IOP of the rabbits was measured by puncture of anterior chamber with 4 1/2 gauge needle connecting physiological recorder, and the diameter of pupil was measured using ruler before usage of the drug and 0.5, 1, 2, 3, 4, 5, 6, 7, 8 hours after application of the drug. BP and HR of the rabbits were detected with carotid artery catheter recorder. Results: Moxonidine caused dose-dependent decreases in IOP. The maximum decreases in IOP were 3.01 mmHg (18.31%). 3.70 mmHg (22.13%), 4.46 mmHg (25.60%) and ocular hypotension lasted for 6, 8 and over 8 hours in ipsilateral eyes at the three doses of moxonidine respectively. In the contralateral eyes the duration of ocular hypotension were shorter, the maximum decreases in IOP were 2.64 mmHg (15.46%), 3.10 mmHg (18.82%) and 2.62 mmHg (16.48%) respectively. All doses of MOX caused significant increases in PD (the maximum increases were 2.6 mm, 3.2 mm and 3.9 mm) in ipsilateral eyes and did not affect HR. The largest dose of MOX reduced diastolic blood pressure. The maximum decreases was 8.85 mmHg (9.93%). The other two doses of MOX didn't affect BP. Conclusion: Moxonidine produces ocular hypotension and small dose and middle dose of moxonidine has no influence on BP and HR when applied topically in rabbit eye. LA: Chinese
Q. Zhang. Department of Ophthalmology, Xi' an No. 4 Hospital, Xi' an 710004, China.
Classification:
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
3.8 Pharmacology (Part of: 3 Laboratory methods)
11.3.3 Apraclonidine, brimonidine (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
