advertisement
Abstract #46687 Published in IGR 13-3
Antioxidant status and oxidative stress in primary open angle glaucoma and pseudoexfoliative glaucoma
Erdurmus M; Yagci R; Atis O; Karadag R; Akbas A; Hepsen IFCurrent Eye Research 2011; 36: 713-718
See also comment(s) by Daniel Won-Kyu Ju •
Purpose: The aim of this study was to establish the antioxidant status and oxidative stress in patients with primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEG). Methods: Serum levels of total antioxidant capacity (TAC) and superoxide dismutase (SOD) as indicators of antioxidant status; and total oxidant status (TOS), nitric oxide (NO), protein carbonyl (PC), and malondialdehyde (MDA) as indicators of oxidative stress were measured from the blood samples of patients with POAG (n = 23), PEG (n = 24) and healthy control subjects (n = 19) by spectrophotometry. Results: Mean TAC level was 0.6 (plus or minus) 0.1 mmol/L in the POAG group; 0.5 (plus or minus) 0.1 mmol/L in the PEG group and 1.2 (plus or minus) 0.3 mmol/L in the control group (p = 0.001). Mean SOD level was 13 (plus or minus) 0.5 mg/L in the POAG group, 11.6 (plus or minus) 0.2 mg/L in the PEG group and 9.4 (plus or minus) 0.6 mg/L in the control group (p = 0.001). Mean TOS level was 19.6 (plus or minus) 2.6 (mu)mol/L in the POAG group, 21.2 (plus or minus) 4.2 (mu)mol/L in the PEG group and 15.1 (plus or minus) 7 (mu)mol/L in the control group (p = 0.001). Mean NO level was 74.3 (plus or minus) 14.4 (mu)mol/L in the POAG group, 66.1 (plus or minus) 8.1 (mu)mol/L in the PEG group and 62.3 (plus or minus) 13.5 (mu)mol/L in the control group (p = 0.005). Mean PC level was 641.5 (plus or minus) 102.5 nmol/mg in the POAG group, 988.3 (plus or minus) 214.7 nmol/mg in the PEG group and 654.4 (plus or minus) 150.7 nmol/mg in the control group (p = 0.001). Mean MDA level was 1.9 (plus or minus) 0.2 (mu)mol/L in the POAG group, 1.7 (plus or minus) 0.4 (mu)mol/L in the PEG group and 1.1 (plus or minus) 0.2 (mu)mol/L in the control group (p = 0.001). Conclusion: The findings of the present study are potentially of significance and add to the growing body of evidence for oxidative stress in POAG and PEG. Decreased antioxidant defense and increased oxidative stress system may play an important role in the pathogenesis of POAG and PEG.
M. Erdurmus. Department of Ophthalmology, Abant Izzet Baysal University, Medical School, Bolu, Turkey.
Classification:
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
3.6 Cellular biology (Part of: 3 Laboratory methods)
