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Abstract #50373 Published in IGR 14-2
Optic disc fluorescein leakage and intraocular pressure in primary open-angle glaucoma
Plange N; Bienert M; Remky A; Arend KOCurrent Eye Research 2012; 37: 508-512
See also comment(s) by Alon Harris •
PURPOSE: To investigate the relationship between increased fluorescein leakage of the optic nerve head and intraocular pressure (IOP), visual field defect, vertical cup-to-disc ratio, disc size and systemic blood pressure in primary open-angle glaucoma (POAG). METHODS: Twenty-seven patients with POAG (aged 63 ± 11 years) and 15 control subjects (aged 58 ± 9 years, p = 0.14) were included in a pilot study. Fluorescein angiography was performed using a Scanning Laser Ophthalmoscope (Rodenstock Instruments, Germany). Fluorescein leakage of the optic disc was quantified using digital image analysis. The change of optic disc fluorescence from 7-8 min to 9-10 min was calculated and correlated to IOP, visual field mean deviation (MD), vertical cup-to-disc ratio, disc size, mean arterial blood pressure (MAP) and ocular perfusion pressure. RESULTS: The change in optic disc fluorescein leakage was significantly increased in patients with POAG compared to control subjects (POAG: 9.7 ± 6.7%; controls: 3.4 ± 4.9%, p = 0.0025). In POAG, fluorescein leakage was significantly correlated to IOP (r = 0.42, p = 0.029), but not to MD (r = -0.13, p = 0.51), vertical cup-to-disc ratio (r = 0.11, p = 0.60) disc size (r = -0.22, p = 0.30), MAP (r = -0.16, p = 0.42) or ocular perfusion pressure (r = -0.32, p = 0.10). In control subjects, a significant correlation was found with vertical cup-to-disc ratios (r = 0.59, p = 0.034), but not to IOP (r = -0.07, p = 0.80), MD (r = -0.26, p = 0.42), disc size (r = -0.10, p = 0.76), MAP (r = 0.09, p = 0.77), or ocular perfusion pressure (r = 0.11, p = 0.72). CONCLUSION: Increased fluorescein leakage of the optic disc was associated with higher IOP levels in patients with POAG. This might reflect a link between vascular damage with increased permeability and uncontrolled IOP.
Department of Ophthalmology, RWTH Aachen University, Aachen, Germany. nplange@ukaachen.de
Full articleClassification:
6.10.2 Posterior segment (Part of: 6 Clinical examination methods > 6.10 Fluorescein (ICG) angiography)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
