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WGA Rescources

Abstract #50391 Published in IGR 14-2

Preclinical models to investigate retinal ischemia: advances and drawbacks

Minhas G; Morishita R; Anand A
Frontiers in neurology 2012; 3: 75


Retinal ischemia is a major cause of blindness worldwide. It is associated with various disorders such as diabetic retinopathy, glaucoma, optic neuropathies, stroke, and other retinopathies. Retinal ischemia is a clinical condition that occurs due to lack of appropriate supply of blood to the retina. As the retina has a higher metabolic demand, any hindrance in the blood supply to it can lead to decreased supply of oxygen, thus causing retinal ischemia. The pathology of retinal ischemia is still not clearly known. To get a better insight into the pathophysiology of retinal ischemia, the role of animal models is indispensable. The standard treatment care for retinal ischemia has limited potential. Transplantation of stem cells provide neuroprotection and to replenish damaged cells is an emerging therapeutic approach to treat retinal ischemia. In this review we provide an overview of major animal models of retinal ischemia along with the current and preclinical treatments in use.

Neuroscience Research Lab, Department of Neurology, Postgraduate Institute of Medical Education and Research Chandigarh, India.

Full article

Classification:

5 Experimental glaucoma; animal models
11.8 Neuroprotection (Part of: 11 Medical treatment)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)



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