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Abstract #55195 Published in IGR 15-4
Comparison of anterior segment morphology following prophylactic laser peripheral iridotomy in Caucasian and Chinese eyes
Lee RY; Kasuga T; Cui QN; Huang G; He M; Lin SCClinical and Experimental Ophthalmology 2014; 42: 417-426
BACKGROUND: To compare anterior segment biometric parameters between Caucasians and Chinese before and after laser peripheral iridotomy (LPI). DESIGN: Prospective clinical cohort study PARTICIPANTS: Caucasian and Chinese primary angle closure suspects. METHODS: Anterior segment optical coherence tomography images captured before and after LPI were analyzed to measure anterior segment biometric parameters. Paired Student's t-tests were used for within-ethnic group comparisons. Univariate and linear mixed-effects regression models were used for between-ethnic group comparisons. MAIN OUTCOME MEASURES: angle opening distance (AOD500, AOD750); angle recess area (ARA750); iris thickness (IT750, IT2000, ITM); iris curvature (ICURV); anterior chamber area (ACA); anterior chamber volume (ACV); and anterior chamber width (ACW). RESULTS: Caucasians had significantly greater preoperative ARA750, ACW, and ICURV and lower preoperative IT2000 compared to Chinese (P<0.05). Ethnic differences in preoperative AOD500, AOD750, IT750, ITCM, ACA, and ACV were insignificant (P>0.05). Significant postoperative increases in AOD500, AOD750, ARA750, ACA, ACV, and ACW along with significant postoperative decrease in ICURV were observed within both ethnic groups (P<0.05). However, the amount of LPI-induced changes in AOD500, AOD750, ARA750, ACA, ACV, ACW, and ICURV did not differ between the two ethnic groups (P>0.05). CONCLUSION: Both Caucasian and Chinese demonstrated opening of anterior chamber angle width (AOD500, AOD750, ARA750), expansion of anterior chamber dimensions (ACA, ACV, ACW), and flattening of iris convexity (ICURV) after LPI. Although certain aspects of anterior segment anatomy differed between Caucasians and Chinese preoperatively, they did not translate into significant ethnic differences in the amount of LPI-induced changes in the anterior segment biometric parameters.
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Classification:
9.3.4 Primary angle closure suspect (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
12.2 Laser iridotomy (Part of: 12 Surgical treatment)