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Abstract #5978 Published in IGR 2-2
Effect of IOP elevation on matrix metalloproteinase-2 in rabbit anterior chamber
Kim CY; Kim SS; Koh HJ; You YS; Seong GJ; Hong YJKorean Journal of Ophthalmology 2000; 14: 27-31
To investigate changes in the level of matrix metalloproteinase-2 (MMP-2) in the anterior chamber of rabbit with intraocular pressure (IOP) elevation. The IOP was elevated with scleral encircling in 12 rabbits. In the control group (four rabbits), IOP was not changed after scleral encircling, and in groups 1 (four rabbits) and 2 (four rabbits), IOP was elevated about 10 and 20 mmHg, respectively, after scleral encircling. At two days after scleral encircling, aqueous sampling was performed and levels of MMP-2 were checked by Western blot and gelatin zymograms. The greater the IOP elevation, the more MMP-2 expression in the anterior chamber by Western blot and gelatin zymograms. The increase in MMP-2 expression in response to IOP elevation may have important implications for the IOP feedback control mechanism.
Dr. C.Y. Kim, Department of Ophthalmology, Yonsei University, College of Medicine, Seoul, Korea
Classification:
2.5 Meshwork (Part of: 2 Anatomical structures in glaucoma)
5 Experimental glaucoma; animal models
