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Abstract #6005 Published in IGR 2-2
Assessment of retinal nerve fiber layer internal reflectivity in eyes with and without glaucoma using optical coherence tomography
Pons ME; Ishikawa H; Gtirses-Ozden R; Liebmann JM; Dou H; Ritch RArchives of Ophthalmology 2000; 118: 1044-1047
OBJECTIVE: To assess the internal reflectivity of the retinal nerve fiber layer in normal, ocular hypertensive, and glaucomatous eyes using optical coherence tomography. METHODS: All patients underwent complete ophthalmic examination and achromatic automated perimetry. Intraocular pressure was 21 mmHg or less for low-tension glaucoma and normal eyes and at least 25 mmHg on two separate occasions in ocular hypertensive and high-tension glaucoma eyes. All glaucomatous eyes had characteristic glaucomatous optic neuropathy and associated achromatic automated perimetry defect. Relative retinal nerve fiber layer internal reflectivity was measured on optical coherence tomography images using a software program of our own design. RESULTS: The authors enrolled 98 eyes (19 normal, 34 ocular hypertensive, 17 high-tension glaucoma, and 28 low-tension glaucoma). Relative internal reflectivity was less in eyes with glaucoma than in normal (p < 0.001, t test) and ocular hypertensive eyes (p < 0.001, t test). There was no difference in relative internal reflectivity between normal and ocular hypertensive eyes (p = 0.32) and between eyes with high-tension glaucoma and low-tension glaucoma (p = 0.43). Internal reflectivity correlated with mean deviation on achromated automatic perimetry (r2 = 0.49, p < 0.001, quadratic regression analysis). CONCLUSIONS: Relative retinal nerve fiber layer internal reflectivity may provide useful information about the extent of retinal nerve fiber layer injury in glaucoma.
Dr. R. Ritch, Department of Ophthalmology, New York Eye and Ear Infirmary, 310 E 14th St, New York, NY 10003, USA
Classification:
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
6.9.2 Optical coherence tomography (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)
