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Abstract #6011 Published in IGR 2-2
Glaucoma screening using the scanning laser polarimeter
Yamada N; Chen PP; Mills RP; Leen MM; Stamper RL; Lieberman MF; Zu L; Stanford DCJournal of Glaucoma 2000; 9: 254-261
PURPOSE: To determine the ability of scanning laser polarimetry (GDx Nerve Fiber Analyzer; Laser Diagnostic Technologies, Inc., San Diego, CA) to separate normal eyes from those considered likely to have glaucoma in a public glaucoma screening. METHODS: A two-day public glaucoma screening program was held at two different institutions. Each subject underwent ophthalmological examination. Humphrey perimetry (24-4 Fastpac program), and imaging using scanning laser polarimetry (GDx) in each eye for allocation into a diagnostic category: normal, ocular hypertensive, glaucoma suspect, or glaucoma. Results from the normal and glaucoma groups were analyzed, using modulation parameters calculated from a measurement band located 1.8 disc diameters from the disc, and selected parameters provided automatically by GDx software. Receiver operating characteristic curves were used to depict the sensitivity/specificity relationship at different GDx parameter cut-off levels. RESULTS: Of 200 subject, 197 were classified: 122 as normal, 23 with ocular hypertension, 30 as glaucoma subjects, and 22 with definite glaucoma. Three subjects had ocular diseases other than glaucoma. The maximum area under the receiver operating characteristic curve for modulation parameters was 0.935, and for the GDx software parameters 0.901. CONCLUSION: Scanning laser polarimetry may be useful in glaucoma screening.
Dr. P.P. Chen, Department of Ophthalmology, University of Washington, Box 356485, Seattle, WA 98195-6485, USA
Classification:
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
6.9.1 Laser scanning (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)
