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Abstract #6112 Published in IGR 2-2
Spontaneous intraocular pressure reduction in normal-tension glaucoma and associated clinical factors
Oguri A; Yamamoto T; Kitazawa YJapanese Journal of Ophthalmology 2000; 44: 263-267
To investigate the intraocular pressure (IOP) reduction in certain normal-tension glaucoma (NTG) patients and clinical factors associated with this reduction. METHODS: Fifty-four NTG patients who met the following enrollment criteria were selected: IOP <21 mmHg during a 24-hour pressure curve and throughout the subsequent 12 months; examined every one to four months for at least three years with no ocular hypotensive therapy. For each patient, the eye with the higher mean IOP during the 24-hour pressure curve was selected for this study. RESULTS: Six patients had an IOP reduction which was defined as a significant decrease (p < 0.05) of IOP over time, determined by the Spearman rank correlation coefficient method. These six eyes were rated positive for subsequent IOP reduction. The IOP reduction was correlated to clinical factors by means of a logistic multiple regression analysis (LOGIST procedure using PC-SAS), which demonstrated that the larger difference between the maximum IOP and the minimum IOP during the initial 24-hour pressure curve and the absence of disc hemorrhage showed significant correlation with IOP reduction (p = 0.026 and p = 0.013, respectively). The odds ratios were 2.05 per 1 mmHg increase of difference between the maximum IOP and the minimum IOP during the initial 24-hour pressure curve and 1.13 for the absence of disc hemorrhage. CONCLUSIONS: The current study demonstrated that a significant reduction of IOP over time is not uncommon in NTG patients. One ninth of the NTG patients in this study showed a significant IOP reduction during a three-year follow-up period.
Dr. A. Oguri, Department of Ophthalmology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu-shi, Gifu-ken 500-8705, Japan
Classification:
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
