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Abstract #6135 Published in IGR 2-2
Pseudoexfoliation syndrome in Australian adults
McCarty CA; Taylor HRAmerican Journal of Ophthalmology 2000; 129: 629-633
PURPOSE: To describe the prevalence and correlates of pseudoexfoliation syndrome in Australians aged 40 years and older. METHODS: Cluster, stratified sampling was employed to identify a cohort representative of the population of the state of Victoria aged 40 years and older that included urban, rural, and nursing home residents. A standardized personal interview and clinical eye examination, including intraocular pressure, were performed at locally established test sites. The presence of any pseudoexfoliation material on the iris or lens capsule was noted on dilated slit-lamp examination. Participants were classified as having pseudoexfoliation syndrome if any pseudoexfoliation material was present in either eye. Univariate analyses with t tests and chi-square were first employed to evaluate risk factors for pseudoexfoliation. Any factors with p < 0.10 were then fitted in a backward stepwise logistic regression model. For the final multivariate models, p < 0.05 was considered statistically significant. RESULTS: A total of 3271 of the urban residents (83% of eligible), 403 nursing home residents (90% of eligible), and 1473 rural residents (92%) participated. The urban residents ranged in age from 40-98 years (mean, 59), and 1511 (46%) were men. The nursing home residents ranged in age from 46-101 years (mean, 82), and 85 (21%) were men. The rural residents ranged in age from 40-103 years (mean, 60), and 701 (47.5%) were men. Participants with bilateral cataract extraction were excluded from further analyses. The overall rate of pseudoexfoliation syndrome in this population was 0.98% (95% confidence limit = 0.57, 1.28). The prevalence of pseudoexfoliation material in either eye increased significantly with age. No cases of pseudoexfoliat ion syndrome were observed in people aged 90 years and older. However, people with bilateral cataract surgery had been excluded from these analyses. After adjusting for age and cataract, only glaucoma remained significantly related to pseudoexfoliation (odds ratio = 3.80, 95% confidence limit = 1.73, 8.33). DISCUSSION: In conclusion, the authors found only two strong correlates of pseudoexfoliation in their population-based sample of Victorians aged 40 years and older: age and glaucoma.
Dr. C.A. McCarty, Centre for Eye Research Australia, East Melbourne, Victoria, Australia. cathy@cera.unimelb.edu.au
Classification:
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
