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Abstract #61424 Published in IGR 17-1

In vivo quantification of cochlin in glaucomatous DBA/2J mice using optical coherence tomography

Wang J; Aljohani A; Carreon T; Gregori G; Bhattacharya SK
Scientific reports 2015; 5: 11092


The expression of cochlin in the trabecular meshwork (TM) precedes the clinical glaucoma symptoms in DBA/2J mice. The ability to quantify cochlin in the local tissue (TM) offers potential diagnostic and prognostic values. We present two (spectroscopic and magnetomotive) optical coherence tomography (OCT) approaches for in vivo cochlin quantification in a periodic manner. The cochlin-antibody OCT signal remains stable for up to 24 hours as seen at 3.5 hours after injection allowing for repeated quantification in the living mouse eyes.

Bascom Palmer Eye Institute, University of Miami, Miami, Florida, 33136.

Full article

Classification:

5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)
2.5.1 Trabecular meshwork (Part of: 2 Anatomical structures in glaucoma > 2.5 Meshwork)
3.13.2.2 Posterior Segment (Part of: 3 Laboratory methods > 3.13 In vivo imaging > 3.13.2 Optical Coherence Tomography)



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