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Abstract #6153 Published in IGR 2-2
Hormonal changes in male patients with primary open angle glaucoma
Nowak M; Swietochowska E; Jochan K; Buntner BKlinika Oczna 2000; 102: 103-108
INTRODUCTION: Primary open-angle glaucoma (POAG) is the most common type of glaucoma, the pathogenesis of which is not completely known. Several clinical studies show that glucocorticoid hormones may be implicated in the pathogenesis of POAG and ocular hypertension. Glucocorticoid receptors have been identified in human outflow tissue of the eye. AIMS: Therefore, the purpose of this study was to evaluate the serum concentration of total cortisol (TF), total testosterone (TT), free testosterone (FT), follitropin (FSH), lutropin (LH), adrenocorticotropin (ACTH), sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEA-SO4), as well as free cortisol (UFF) and 17-OHCS in 24-hour urinary samples in patients treated for POAG. PATIENTS AND METHODS: Studies were performed in a group of 30 male patients, aged 55 ± 13 years, who had been treated for glaucoma for more than two years. Serum and urinary concentration of hormones were studied using RIA methods (DPC). RESULTS: The serum concentration of TF (652.03 ± 315.43 nmol/l), UFF (248.75 ± 99.39 nmol/l) and 17-OHCS (5.47 ± 2.64 mg/24 hour) in the urine was increased compared with a control group. There was no significant difference in the concentration of pituitary-gonadal axis hormones in the glaucomatous and control groups. CONCLUSIONS: The results could point to the fact that changes in the endocrine system are one of the factors involved in the pathogenesis of POAG. The authors conclude that an elevated level of cortisol, free cortisol and its metabolites is closely related to POAG. LA: Polish
Dr. M. Nowak, Zakladu Patofizjologii i Endokrynologii Slaskiej AM w Zabrzu, Poland
Classification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)