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Abstract #6365 Published in IGR 3-2
Patterns of retinal ganglion cell survival after brain-derived neurotrophic factor administration in hypertensive eyes of rats
Ko ML; Hu DN; Ritch R; Sharma SC; Chen CFNeuroscience Letters 2001; 305: 139-142
The authors investigated the effect of brain-derived neurotrophic factor (BDNF) on retinal ganglion cell (RGC) survival after intraocular pressure (IOP) elevation at various time intervals. In adult Wistar rats, RGCs were labelled with 5% Fluorogold. Animals with 1.8-2.5-fold increases in IOP after cauterization of three episcleral vessels, were divided into three BDNF groups and three vehicle control groups, each receiving one, two or three injections. The RGC survival percentage on RGCs of the first, second and third injections were 93.9% (n = 7), 91.3% (n = 7), 82.7% (n = 5), respectively, in BDNF groups; 91.6% (n = 6), 84.1% (n = 6) and 73.5% (n = 5), respectively, in vehicle controls. The second and third injections of BDNF showed statistically significant survival effects. These findings demonstrated that BDNF has partial neuroprotection on RGCs in whole retina and enhances RGC survival in moderately chronic hypertensive eyes.
Dr M.L. Ko, Department of Physiology, National Taiwan University, 1, Section 1, Jen-Ai Road, 10018, Taipei, Taiwan
Classification:
5 Experimental glaucoma; animal models
11.8 Neuroprotection (Part of: 11 Medical treatment)
