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Abstract #74344 Published in IGR 19-1
High intraocular pressure produces learning and memory impairments in rats
Yuan Y; Chen Z; Li L; Li X; Xia Q; Zhang H; Duan Q; Zhao YBrain Research 2017; 1675: 78-86
See also comment(s) by Luciano Quaranta •
Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide. Previous MRI studies have revealed that POAG can be associated with alterations in hippocampal function. Thus, the aim of this study was to investigate a relationship between chronic high intraocular pressure (IOP) and hippocampal changes in a rat model. We used behavioural tests to assess learning and memory ability, and additionally investigated the hippocampal expression of pathological amyloid beta (Aβ), phospho-tau, and related pathway proteins. Chronic high IOP impaired learning and memory in rats and concurrently increased Aβ and phospho-tau expression in the hippocampus by altering the activation of different kinase (GSK-3β, BACE1) and phosphatase (PP2A) proteins in the hippocampus. This study provides novel evidence for the relationship between high IOP and hippocampal alterations, especially in the context of learning and memory.
Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Full articleClassification:
15 Miscellaneous
5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)
