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Abstract #84954 Published in IGR 21-1
Visual Impairment and Major Eye Diseases in Chronic Kidney Disease: The National Health and Nutrition Examination Survey 2005 to 2008
Zhu Z; Liao H; Wang W; Scheetz J; Zhang J; He MAmerican Journal of Ophthalmology 2020; 0:
PURPOSE: To investigate the prevalence and associations of visual impairment (VI), major eye diseases with chronic kidney disease (CKD) in the US. DESIGN: Cross-sectional study. METHODS: We investigated the prevalence and associations of VI, major eye diseases with CKD among 5,518 participants aged 40 years or older in the 2005-2008 National Health and Nutrition Examination Survey. An estimated glomerular filtration rate of lower than 60 ml/min/1.73m was defined as CKD. Corrected visual acuity of worse than 20/40 in the better-seeing eye was defined as VI. Major eye diseases, including any ocular disease, any objectively-determined ocular disease, cataract surgery, any retinopathy, diabetic retinopathy (DR), age-related macular degeneration (AMD) and glaucoma were evaluated from questionnaire or retinal photographs using standardized grading protocols. RESULTS: The prevalence of VI and major eye diseases were approximately two to seven-fold higher in participants with CKD than in those without (all P<0.05). After controlling for multiple confounders, the presence of CKD was associated with VI (odds ratio[OR]:2.01,95% confidence interval[CI]:1.14-3.54), any ocular disease (OR:1.65,95% CI:1.22-2.22), any objectively-determined ocular disease (OR:1.52;95% CI: 1.06-2.19), any retinopathy (OR:1.70,95% CI:1.18-2.45) and DR (OR:2.34,95% CI:1.23-4.42). There was no association of CKD with cataract surgery, AMD or glaucoma. A significant association between CKD and any ocular disease was observed among non-diabetic participants. The presence of CKD was closely related to VI and any retinopathy among diabetic participants. CONCLUSIONS: This nationally representative sample of the US population demonstrated high prevalence and strong associations of VI and major eye diseases with CKD, highlighting the importance of ocular screening among CKD patients and potential common pathogenesis underlying these conditions.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Full articleClassification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)