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Abstract #8532 Published in IGR 5-1
Effects of olprinone hydrochloride on intraocular pressure and ocular blood flow in patients after cardiac surgery under cardiopulmonary bypass
Goto K; Hasegawa A; Shingu C; Hayano Y; Yoshitake S; Noguchi TJapanese Journal of Anesthesiology 2002; 51: 1212-1216
BACKGROUND: The authors evaluated the effect of olprinone hydrochloride on intraocular pressure (IOP) and ocular blood flow in patients after cardiac surgery under cardiopulmonary bypass (CPB). METHODS: Nine patients after cardiac surgery under CPB were investigated. The authors measured IOP of the left eye using tonometer (Tonopen XLR, BIO RAD, Osaka), and mean blood flow velocity in the left ophthalmic artery (Vm) and calculated the pulsatility index in the left ophthalmic artery (PI) using 2 MHz Doppler ultrasound system (Multidop PR, DWL, Germany). After baseline measurement, the olprinone hydrochloride loading dosage was increased from 0.15-0.3 μg · kg-1 · min-1 every 60 minutes. IOP and ocular blood flow were measured at each point. RESULTS: IOP and PI decreased significantly, and Vm increased significantly at the infusion rate of 0.3 μg · kg-1 · min-1 from baseline. There was a significant linear correlations between IOP and Vm. CONCLUSION: The authors demonstrated that olprinone hydrochloride led to a decrease in IOP and an increase in ocular blood flow in patients after cardiac surgery under CPB.LA: Japanese
Dr. K. Goto, Division of Anesthesia, Miyazaki Prefecture Nobeoka Hospital, Nobeoka 882-0835, Japan
Classification:
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
