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Abstract #86687 Published in IGR 21-2

Association of High-Mobility Group Box-1 with Inflammation-Related Cytokines in the Aqueous Humor with Acute Primary Angle-Closure eyes

He W; Xu F; Chen L; Huang W; Jiang L; Tang F; Yan W; Zhong S; Shen C; Huang H; Lv J; Wu X; Zeng S; Li M; Zhang M
Current Molecular Medicine 2020; 0:


PURPOSE: AIM: ing at measuring levels of High-mobility group box-1 (HMGB1) and inflammation-related cytokines in the aqueous humor of patients with acute primary angle-closure glaucoma (APAG) and age-related cataract eyes (ARC). METHODS: Aqueous humor samples were obtained from 59 eyes of 59 Chinese subjects(APAG, 32 eyes; and ARC, 27eyes). The multiplex bead immunoassay technique was used to measure the Levels of HMGB1 and IL-8, IL-6, G-CSF, MCP-3, VEGF, sVEGFR-1, sVEFGR-2, TNF-α, PDGF and IL-10 in aqueous. The data of Patients' demographics and preoperative intraocular pressure (IOP) were also gathering for related analysis. RESULTS: The APAG group showed significantly elevated concentrations of HMGB1, IL-8, IL-6, G-CSF, VEGF, sVEGFR-1 and TNF-α than those in ARC group. Aqueous HMGB1 level correlated significantly with IOP, IL-8, IL6, G-CSF and sVEGFR-1 levels but not with age, TNF-α or VEGF levels. CONCLUSIONS: The aqueous level of HMGB1 is elevated in APAG and is associated with aqueous level of inflammation-related cytokines, suggesting an association between elevated levels of HMGB1, APAC and certain inflammatory modulators which, of course, should lead to further investigations in order to demonstrate cause and effect.

Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi. China.

Full article

Classification:

9.3.1 Acute primary angle closure glaucoma (pupillary block) (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
2.6.3 Compostion (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics)
3.10 Immunobiology (Part of: 3 Laboratory methods)



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