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Abstract #9763 Published in IGR 5-3

Contrast sensitivity improves after brimonidine therapy in primary open angle glaucoma: a case for neuroprotection

Evans DW; Hosking SL; Gherghel D; Bartlett JD
British Journal of Ophthalmology 2003; 87: 1463-1465


AIMS: To determine the visual outcome following initiation of brimonidine therapy in glaucoma. METHODS: Sixteen newly diagnosed previously untreated glaucoma patients were randomly assigned to either timolol 0.5% or brimonidine 0.2%. Visual acuity, contrast sensitivity (CS), visual fields, intraocular pressure (IOP), blood pressure, and heart rate were evaluated at baseline and after three months. RESULTS: IOP reduction was similar for both groups (p < 0.05). Brimonidine improved CS; in the right eye at 6 and 12 cpd (p = 0.043, p = 0.017); in the left eye at 3 and 12 cpd (p = 0.044, p = 0.046). Timolol reduced CS at 18 cpd in the right eye (p = 0.041). There was no change in any other measured parameters. CONCLUSION: Glaucoma patients exhibit improved CS on initiation of brimonidine therapy.

Dr. D.W. Evans, School of Optometry, University of Alabama at Birmingham, Birmingham, AL, USA


Classification:

6.6.3 Special methods (e.g. color, contrast, SWAP etc.) (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
11.8 Neuroprotection (Part of: 11 Medical treatment)



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