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Abstract #9807 Published in IGR 5-3
Reproducibility of retinal and optic nerve head perfusion measurements using scanning laser Doppler flowmetry
Hafez AS; Bizzarro RLG; Rivard M; Trabut I; Lovasik JV; Kergoat H; Lesk MROphthalmic Surgery Lasers and Imaging 2003; 34: 422-432
BACKGROUND AND OBJECTIVE: To evaluate the reproducibility of full-field perfusion analysis using scanning laser Doppler flowmetry (SLDF) for perfusion measurements of the neuroretinal rim of the optic nerve head and the peripapillary retina in patients with open-angle glaucoma or ocular hypertension, and in normal subjects. PATIENTS AND METHODS: SLDF perfusion measurements of the neuroretinal rim and the peripapillary retina were performed in 20 patients with open-angle glaucoma or ocular hypertension (group G) and 20 normal volunteers (group N). Each subject underwent two independent sessions, 30 minutes apart, each involving five high quality images. Intrasession and intersession reproducibility coefficients for flow, volume, and velocity were calculated for a single image and for means of three and five images using analysis of variance models. RESULTS: Using a mean of five measurements for flow, the intrasession coefficient of reliability was 0.99 each for the rim, nasal retina, and temporal retina in group G and 0.93, 0.93, and 0.95, respectively, in group N. The intersession coefficient of reliability for flow was 0.99 for the rim, 0.95 for the nasal retina, and 0.87 for the temporal retina in group G and 0.87, 0.82, and 0.80, respectively, in group N. Compared with single image analysis, intrasession and intersession reproducibility were generally better when a mean of three images and substantially better when a mean of five images was used. CONCLUSIONS: SLDF full-field perfusion analysis is markedly more reproducible than the original software using 10 x 10 pixel windows. Obtaining mean values for at least three images improves the intrasession and intersession reproducibility of this technique.
Dr. M.R. Lesk, Department of Ophthalmology, Maisonneuve-Rosemont Hospital, 5689 Rosemont Boulevard, Montreal, Quebec H1T 2H1, Canada
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
