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Abstract #98548 Published in IGR 22-4
The genetics of glaucoma: Disease associations, personalised risk assessment and therapeutic opportunities-A review
Aboobakar IF; Wiggs JLClinical and Experimental Ophthalmology 2022; 50: 143-162
Glaucoma refers to a heterogenous group of disorders characterised by progressive loss of retinal ganglion cells and associated visual field loss. Both early-onset and adult-onset forms of the disease have a strong genetic component. Here, we summarise the known genetic associations for various forms of glaucoma and the possible functional roles for these genes in disease pathogenesis. We also discuss efforts to translate genetic knowledge into clinical practice, including gene-based tests for disease diagnosis and risk-stratification as well as gene-based therapies.
Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.
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