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Abstract #126721 Published in IGR 25-2

Aqueous humor cytokines levels and illuminated microcatheter-assisted circumferential trabeculotomy outcome in open-angle glaucoma patients: a 24-month prospective study

PURPOSE: To investigate the influence of aqueous humor cytokines levels on the failure of illuminated microcatheter-assisted circumferential trabeculotomy (MAT) in open-angle glaucoma (OAG) patients. METHODS: This was a prospective case series with a follow-up period of 24 months. General information and ocular examinations were recorded. Aqueous humor was collected at the time of surgery. Eight aqueous humor cytokines were analyzed: CCL2, VCAM-1, ICAM-1, IL-6, IL-8, IL-10, CXCL10 and G-CSF. Bioinformatics analysis was used to explore the protein network and the possible pathways related to OAG. Surgical failure was defined as a requirement for glaucoma reoperation or intraocular pressure (IOP) greater than 21mmHg with more than 3 topical antiglaucoma medications at 24-month follow-up. RESULTS: Sixty-five eyes were enrolled (58 success and 7 failure). The levels of CCL2, ICAM-1, IL-6 and CXCL10 in aqueous humor were significantly higher in the surgical failure group ( = 0.024, 0.002, 0.022 and 0.008, respectively). A higher percentage of secondary glaucoma ( < 0.001), younger age ( = 0.019), worse preoperative BCVA ( = 0.022), higher preoperative IOP ( = 0.022) and more preoperative topical antiglaucoma medications ( = 0.029) were significantly observed in the surgical failure group. Bioinformatics analysis identified 4 hub proteins, including CCL2, CXCL10, IL-6 and CXCR3, and demonstrated the potential role of chemokine signaling pathway in MAT surgical outcome. CONCLUSION: Higher concentrations of CCL2, ICAM-1, IL-6 and CXCL10 in the aqueous humor were related to the failure of MAT surgery in OAG patients, and chemokine signaling pathway might be associated with the surgical outcome.

Classification:

15 Miscellaneous

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