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Abstract #127163 Published in IGR 25-3
Targeting mitochondrial dysfunction: Innovative strategies to combat glaucoma neuroinflammation
Lu W; Liao Z; Jiang X; Peng M; Deng Q; Zhou X; Lu M; Duan XExperimental Eye Research 2025; 257: 110441
Glaucomatous optic neuropathy represents a prevalent optic nerve degenerative disease. Neuroinflammation is recognized as a significant mechanism underlying optic nerve damage in glaucoma; however, the precise mechanisms driving neuroinflammation remain largely elusive. Existing studies have indicated that microglia-driven neuroinflammation is pivotal for neuroinflammation onset and progression. Mitochondrial dysfunction, encompassing mitochondrial DNA (mtDNA) damage, metabolic deficiencies, and quality control impairments, is upstream of microglial activation and neuroinflammation. Thus, a deeper comprehension of the link between mitochondrial dysfunction and microglial activation in glaucoma may provide valuable insights into the underlying pathogenesis. As a result of these findings, promising avenues for developing effective interventions to mitigate optic nerve damage and preserve visual function in glaucoma patients have been identified.
Hunan Provincical Key Laboratory of Neurorestoratology, Ophthalmology Department of 921 Hospital of Joint Logistics Support Force People's Liberation Army of China (The Second Affiliated Hospital of Hunan Normal University), Changsha, Hunan, 410003, China.
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