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Abstract #127565 Published in IGR 25-3
Outcomes of laser peripheral iridotomy in subgroups of primary angle closure disease eyes according to swept-source optical coherence tomography parameters
Wang LF; Xiang HT; Chen SJ; Jiang SM; Zhang JY; Tang XL; Lin H; Li NEye 2025; 39: 2042-2050
AIMS: This study aimed to examine the impact of laser peripheral iridotomy (LPI) on subgroups of primary angle closure eyes based on swept-source optical coherence tomography (SS-OCT). METHODS: SS-OCT was used to image 115 eyes with primary angle-closure disease (PACD) at prior to LPI, 1 week, 4 weeks and 12 weeks after LPI. A hierarchical cluster analysis was conducted to classify PACD eyes into subgroups based on pre-LPI SS-OCT parameters. The primary parameters were then compared after LPI to assess any variations in the outcomes among the identified subgroups. A mixed-effects model was used to evaluate the difference between subgroups and the effect of LPI. RESULTS: The hierarchical cluster analysis resulted in the identification of two distinct clusters. Cluster 1 (56 eyes) exhibited larger lens vault, pupil distance, iris volume, iris area, iris thickness 2000, as well as narrower angles (p < 0.05 for all). Cluster 2 (59 eyes) had smaller anterior chamber width and anterior chamber volume (p < 0.05 for all). Following LPI, there was an observed increase in the angle size and a decrease in irido-trabecular contact index (ITCI) in both clusters (p < 0.05 for all). Over a period of 3 months, the cluster 1 exhibited stability in angle size and ITCI, whereas cluster 2 exhibited a gradual decline in angle size and a gradual increase in ITCI (p < 0.05 for all). CONCLUSION: This study successfully identified two distinct subgroups of PACD eyes based on SS-OCT parameters. Smaller eyes demonstrated a declining response to LPI over a period of 3 months.
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, 610041, China.
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