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Abstract #127636 Published in IGR 25-3
Dynamic regulation of thermal-responsive fibers for mitomycin C-controlled delivery on glaucoma drainage device implantation
Ma J; Wang L; Dong A; Zhang S; Guo T; Han Y; Jiang M; Fan P; Song W; Zhang F; Leng J; Yuan HBiomaterials advances 2025; 176: 214359
Bleb fibrosis remains the most common reason for glaucoma surgery failure. Although mitomycin C (MMC) is often used to inhibit fibrosis during glaucoma drainage device (GDD) implantation, the effective reaction time of anti-fibrosis could not cover the dynamic process of wound healing. To enable noninvasive dynamic ocular drug release, we fabricated MMC-loaded thermos-responsive fiber membranes using polylactic acid (PLA) and tributyl citrate as a plasticizer. The fibers exhibited a transition temperature of 41.5 °C. To regulate drug delivery, the fiber was first stretched, coated on the GDD surface, and then implanted in rabbit eyes. The thermal-responsive fiber recovered to its original morphology upon exposure to a 43 °C stimulus in filtering bleb area one week postoperatively. The release profiles in vitro were described best by the first-order kinetics. The release rate constants were k = 0.11 ± 0.01 day and k = 0.09 ± 0.02 day, respectively. The controlled release system effectively reduced the bleb fibrosis in rabbit conjunctiva. This MMC-controlled delivery system successfully inhibited scarring after GDD implantation surgery.
Department of Ophthalmology, The Future Medicine Laboratory, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin 150086, People's Republic of China.
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