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Abstract #128518 Published in IGR 25-3
Recent advances in congenital nanophthalmos: a comprehensive literature review
Luo NC; Zuo CG; Liu XChinese Journal of Ophthalmology 2025; 61: 391-396
Nanophthalmos is an uncommon developmental ocular disorder characterized by a diminutive eye resulting from impaired growth, which may occur sporadically or within familial contexts. Both environmental and genetic factors are implicated in the induction of nanophthalmos. The ocular biometric characteristics associated with nanophthalmos include reduced ocular axis, shallow anterior chamber, thickened scler and microcornea, which may lead to complications such as secondary uveal effusion syndrome and angle-closure glaucoma, as well as comorbidities like congenital cataract. Typically, the diagnosis of nanophthalmos is primarily reliant on the measurement of axial length via ultrasound. This review provides a comprehensive overview of the etiology, clinical manifestations, diagnostic criteria, and therapeutic approaches related to nanophthalmos.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology Visual Science, Guangzhou 510060, China.
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