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Abstract #15525 Published in IGR 1-3
Effect of dorzolamide and latanoprost on intraocular pressure after small incision cataract surgery
Rainer G; Menapace R; Schmetterer K; Findl O; Georgopoulos M; Vass CJournal of Cataract and Refractive Surgery 1999; 25: 1624-1629
PURPOSE: To evaluate the effect of dorzolamide 2% and latanoprost 0.005% on intraocular pressure (IOP) after small incision cataract surgery. SETTING: Department of Ophthalmology, University of Vienna, Vienna, Austria. METHODS: This prospective study comprised 102 eyes of 102 consecutive patients scheduled for small incision cataract surgery. The patients were assigned preoperatively to one of three groups of 34 each: dorzolamide, latanoprost, and control (no treatment). One drop of the assigned medication was instilled immediately after surgery. Intraocular pressure was measured preoperatively and six and 20-24 hours postoperatively. RESULTS: Six hours after surgery, the mean increase in IOP was 1.9±3.9 mmHg (SD) in the dorzolamide group (p=0.004 versus control), 2.2±3.0 mmHg in the latanoprost group (p=0.005 versus control), and 4.8±5.2 mmHg in the control group. Twenty to 24 hours postoperatively, IOP decreased by a mean of -0.9±3.5 mmHg in the dorzolamide group (p=0.012 versus control) and increased by a mean of 0.3±3.6 mmHg in the latanoprost group (p=0.24 versus control) and 1.3±4.2 mmHg in the control group. One eye in the dorzolamide group, one in the latanoprost group, and four in the control group had an IOP of 30 mmHg or higher six hours postoperatively. CONCLUSION: Six hours postoperatively, dorzolamide and latanoprost were effective in reducing the IOP increase after small incision cataract surgery; however, at 20-24 hours, only dorzolamide was effective. Neither drug prevented IOP spikes of 30 mmHg or higher.
Dr. G. Rainer, Department of Ophthalmology, University of Vienna, Vienna; Austria
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)
12.12.3 Phacoemulsification (Part of: 12 Surgical treatment > 12.12 Cataract extraction)
