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Abstract #15591 Published in IGR 1-3
Effect of tranilast eyedrops in preventing posterior capsule opacification: preliminary report
Tobari I; Iwaki Y; Mihake KJournal of Cataract and Refractive Surgery 1999; 25: 1394-1399
PURPOSE: To evaluate the effect of tranilast eyedrops in preventing fibrous opacification of the posterior lens capsule after cataract extraction and intraocular lens (IOL) implantation. SETTING: The Second Department of Ophthalmology, Toho University School of Medicine, Tokyo, and Shohzankai Medical Foundation, Miyake Eye Hospital, Nagoya, Japan. METHODS: This study comprised eyes with continuous curvilinear capsulorhexis and phacoemulsification/aspiration followed by implantation of a posterior chamber IOL in the capsular bag. In this prospective, randomized, controlled, and double-masked trial, tranilast 0.5% (Rizaben ®) eyedrops (15 eyes) or its placebo eyedrops (20 eyes) were given four times a day for three months after surgery. An anterior eye segment analysis system (EAS 1000, Nidek Co., Ltd.) was used to evaluate the degree of fibrous posterior capsule opacification (PCO) at one week and one and three months after surgery. RESULTS: The mean PCO density in the tranilast group was 17.1±4.6 cct (SD), 20.0±3.6 cct, and 23.0±6.6 cct (cct: computer compatible tape) at one week and one and three months, respectively. In the control group, this was 18.2±5.3, 30.2±7.8, and 38.4±6.0 cct, respectively. There was a significant difference in the one- and three-month findings between the two groups (p < 0.001). CONCLUSIONS: Tranilast was effective in preventing fibrous PCO at an early postoperative stage. The possible mechanism for its effect may be prevention of collagen synthesis by minimizing transforming growth factor type β released during lens epithelial cell metaplasia.
Dr. I. Tobari, Second Department of Ophthalmology, Toho University School of Medicine, 2-17-6 Ohashi, Meguro-ku, Tokyo 153-0044; Japan
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
12.12.3 Phacoemulsification (Part of: 12 Surgical treatment > 12.12 Cataract extraction)
