Abstract #45594 Published in IGR 13-2

Optic nerve sheath diameter in normal-tension glaucoma patients

Jaggi GP; Miller NR; Flammer J; Weinreb RN; Remonda L; Killer HE
British Journal of Ophthalmology 2011;

See also comment(s) by Ningli Wang & Diya Yang & Beijing iCOP study group

Background: To report on the optic nerve sheath diameter (ONSD) in patients with normal-tension glaucoma (NTG) compared with controls without known optic nerve (ON) or intracranial disease. Methods: In 18 patients with NTG (mean age 64.9(plus or minus)8.9 years; 7 women and 11 men), CT of the orbit was performed. 17 age- and gender-matched patients without ON or intracranial disease, who underwent CT of the orbits for non-ophthalmological reasons, served as controls. The widest intraorbital ONSD in axial sections was measured using a standardised technique. Study design: unmasked. Statistical analysis was performed using an independent two-tailed t Test and the non-parametric Spearman correlation test. Results: ONSD was significantly (p<0.001) increased in NTG patients (right side: mean 7.9(plus or minus)0.9 mm SD; left: 8.0(plus or minus)1.1 mm) compared with controls (right: 6.3(plus or minus)0.5 mm; left: 6.1(plus or minus)0.6 mm). Neither the NTG nor the control group had a significant difference in ONSD between males and females or between right and left sides. Conclusions: An increased ONSD is generally associated with increased intracranial pressure; however, ONSDs in a group of NTG patients also were significantly increased compared with controls. ON sheath compartmentation and thinning of the ON sheath are two possible explanations for an increase in the ONSD in patients with NTG.

H.E. Killer. Kantonsspital Aarau, Buchserstrasse, CH-5001 Aarau, Switzerland, . Email:


9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)

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