advertisement
Abstract #48334 Published in IGR 13-4
Evaluation of Sustained Release of PLC-Loaded Prednisolone Acetate Microfilm on Postoperative Inflammation in an Experimental Model of Glaucoma Filtration Surgery
Ang M; Yan P; Zhen M; Foo S; Venkatraman SS; Wong TTCurrent Eye Research 2011; 36: 1123-1128
PURPOSE: To evaluate the effect of a biodegradable microfilm with sustained release of prednisolone acetate (PA) on postoperative wound healing after experimental glaucoma filtration surgery (GFS). METHODS: Biodegradable microfilms composed of poly (d-, l-lactide-co-caprolactone) (PLC) were fabricated and then pre-loaded PA-20% total weight. Fourteen New Zealand White rabbits were randomly divided into 3 treatment groups: GFS alone (n?=?4), GFS with PLC microfilms (n?=?4) and GFS with PA-loaded microfilm (n?=?6). Microfilms were inserted subconjunctivally, adjacent to the filtering surgical site. We monitored all eyes with slit-lamp examination, bleb photography and anterior segment optical coherence tomography (AS-OCT). Histology with immunohistochemistry was performed to determine the presence of any inflammation. RESULTS: Prednisolone acetate 20%-loaded microfilms exhibited steady, sustained release in vitro. Eyes implanted with PA-loaded microfilms showed a significantly better bleb survival (100% vs. 37.5%, p?
Singapore National Eye Centre , Singapore.
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
