Abstract #49262 Published in IGR 14-1

Structure-Function Relationships between Spectral-Domain OCT and Standard Achromatic Perimetry

Nilforushan N; Nassiri N; Moghimi S; Law SK; Giaconi J; Coleman A; Caprioli J; Nouri-Mahdavi K
Investigative Ophthalmology and Visual Science 2012; 53: 2740-2748

PURPOSE: To explore structure-function relationships in early glaucoma with spectral-domain optical coherence tomography (SD-OCT) and standard achromatic perimetry. METHODS: One hundred thirty-six eyes of 97 patients with suspected or early glaucoma were enrolled from the clinical database at UCLA's Glaucoma Division. All patients had good-quality peripapillary retinal nerve fiber layer (RNFL)/optic disc measurements (Optic Disc Cube 200x200, Cirrus HD-OCT) and a reliable 24-2 SITA-Standard Humphrey visual field (VF) within a 6-month period. Correlations of global and sectoral RNFL thickness and rim area (RA) measurements with corresponding global and regional VF sensitivities (both in logarithmic [dB] and 1/Lambert scales [1/L]) were investigated with components of variance model. RESULTS: The average RNFL thickness, RA, and mean deviation (MD) were 85.6 ± 5.7 µ, 1.0 ± 0.3 mm2, and -1.3 ± 1.9 dB, respectively. Global RA demonstrated a stronger correlation with MD compared to average RNFL thickness (p=0.002). The highest correlations were observed between superonasal VF cluster (in dB scale) and inferotemporal RA (R2= 0.26, 95% CI: 0.15-0.40) or inferotemporal RNFL thickness (R2= 0.24, 95% CI: 0.13-0.37). In glaucoma suspects, the highest correlations were seen between superonasal VF cluster and inferotemporal RA (R2=0.16) in dB scale or RNFL thickness (R2=0.10) in 1/L scale. Correlations were slightly greater with dB scale than 1/L scale and tended to be linear with both scales. CONCLUSIONS: Structure-function relationships can be detected in early glaucoma with SD-OCT. Correlations of RA with VF thresholds tended to be higher compared to those of RNFL. Structure-function relationships were well described with a linear model.

Glaucoma Division, Jules Stein Eye Institute, Los Angeles, CA, USA.

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6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests) Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)

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