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Abstract #6163 Published in IGR 2-2
Adverse effects of topical antiglaucoma drugs on the ocular surface
Arici MK; Arici DS; Topalkara A; Guler CClinical and Experimental Ophthalmology 2000; 28: 113-117
PURPOSE: This study was designed to determine the effect of long-term antiglaucoma topical medication on the ocular surface, measuring basal Schirmer's and tear break-up time tests using conjunctival impression cytology. METHODS: The ocular surfaces of 30 control subjects (group 1), 24 primary open-angle glaucoma patients treated with 0.5% betaxolol hydrochloride (group 2), 27 primary open-angle glaucoma patients treated with 0.5% timolol maleate (group 3), and 26 primary open-angle glaucoma patients treated with 0.5% betaxolol and 1% dipivefrin hydrochloride (group 4), were evaluated. Basal Schirmer's and tear break-up time tests were measured and ocular surface changes were determined by impression cytology. Impression cytology specimens of each group were graded and scored in the range 0-3 according to Nelson's method. RESULTS: Patients in groups 2, 3 and 4 showed statistically significant fewer normal basal Schirmer's tests (wettability) and tear break-up time tests (p < 0.01). Also, the conjunctival impression cytology scores were significantly higher in groups 2, 3 and 4 than in group 1 (p < 0.01). CONCLUSIONS: It is possible that conjunctival surface and tear film function change after the long-term use of antiglaucoma medication.
Dr. M.K. Arici, Cumhuriyet Universitesi, Tip Fakultesi, Goz ABD-58140 Sivas, Turkey
Classification:
11.1 General management, indication (Part of: 11 Medical treatment)
